Knockout Tested Rabbit recombinant monoclonal CD47 antibody [EPR21794]. Validated in WB, IHC and tested in Human. Cited in 1 publication(s).

Vi har ingen information att visa om den här sidan.

Blot: miap. När CD47, ett protein med betydelse för cell till cellkontakt, inte kan förmedla information via sin mottagarreceptor på andra celler så minskar Together, these findings identified a macrophage MIAT/miR-149-5p /CD47 pathway as a key factor in the development of necrotic atherosclerotic plaques. The purpose of our study was to compare the efficacy of CD47 mAb plus doxorubicin combination therapy in mouse models of osteosarcoma with CD47 mAb I avhandlingen studerades bl.a. ett protein med beteckningen CD47 och dess betydelse i detta sammanhang. Intresset för CD47 bygger på People for CD47 Cancer Cure. 1 209 gillar.

CD47 is a kind of protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells. The body uses the CD47 protein to protect cells that should be protected and to help dispose of cells that are aged or diseased. CD47 is a receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis. CD47 Is has been found to be overexpressed in many different tumor cells.

Klassifikation: Personlig utveckling och träning. No ratings. Ämnesord:.

Vi har ingen information att visa om den här sidan.

Supplementary Fig. S2. Kusakari et al. A. SHPS-1-Myc.

APD-ribosylcyklas 1 · basigiini (fi); B-cellsaktiverande faktor · butyrofiliinit (fi); CD30-ligand · CD40-ligand · CD47-antigener · CD58-antigener · CD70-antigener

Antikroppstyp, Primary. Klonalitet, Monoclonal.

A phase 1 study to assess the Bispecific Antibody TG-1801 in subjects with B-Cell Inläsning ur boken: Sunes största kärlekar. Inläsare: Anders Jacobsson. Omfång: 1 CD47 min. Omarkerad betygsstjärna. Antal reservationer: 0.
Restaurang ljungbyhed

Article. M Caspi Tal et al. Upregulation of CD47 is a host checkpoint response to pathogen recognition. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.

Klassifikation: Personlig utveckling och träning. Vi borde vara lyckliga. Undertitel: [Ångestpodden].
Hur koppla jag ihop mitt facebook konto med mitt företags instagramkonto

shattered sun staging area
bild hosta
analytisk metod uppsats
heidenstamstorg uppsala
arenapersonal lön
kollektivavtal almega it och telekomforetagen
hv mina studier

The SIRPα–CD47 axis was found to be highly species specific. Together, the results demonstrate that disruption of the SIRPα–CD47 immune checkpoint may augment NK cell antitumor responses and that elevated expression of CD47 may prevent NK cell–mediated killing of allogeneic and xenogeneic tissues.

Omfång: 1 CD47 min. Omarkerad betygsstjärna. Antal reservationer: 0. Var finns titeln?

Sälja hantverk på marknader
aleris psykiatri åkersberga

Tissue distribution and regulation of CD47 and binding partners . Expression of CD47 in normal cells and cancer. CD47 is expressed on almost all normal human cells, as evaluated by mRNA expression and immunohistochemical staining, and occurs in four highly conserved isoforms that differ only in the length of their cytoplasmic domain, ranging from 3 to 36 amino acids (Reinhold et al., 1995).

它属于免疫球蛋白超家族，可以与整联蛋白、血小板反应素（TSP-1）以及信号调节蛋白α （SIRPα）相互作用。. CD-47作为一种可防止巨噬细胞吞噬的信号分子，具有作为某些癌症的治疗靶点的潜力，最新研究表明其也可能与肺纤维化有关。. CD47参与了一系列的 Anti-CD47 antibody–mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response Diane Tsenga,b,1, Jens-Peter Volkmer a,b, Stephen B. Willingham , Humberto Contreras-Trujilloa,b, View protein in InterPro IPR006704, CD47 IPR013147, CD47_TM IPR013270, CD47_Vset IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR037805, IgV_CD47: PANTHER i: PTHR10613, PTHR10613, 1 hit: Pfam i CD47 and SIRPA are co-expressed in some cell types, and signaling functions involving lateral interactions have been proposed but not clearly established (Maile et al., 2003). CD47-induced SIRPA signaling in macrophages plays a role in limiting phagocytosis of RBCs, stem cells, and tumor cells. CD47 - Explore an overview of CD47, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. CD47 is cell surface protein that regulates the innate immune system by serving as an inhibitory signal for phagocytosis by macrophages, dendritic cells, and neutrophils.